Every time I open solution in Visual Studio 2015 I get following message:

Here are last entries from ActivityLog.xml:
<entry>
   <record>827</record>
   <time>2015/12/23 11:26:13.919</time>
   <type>Error</type>
   <source>VisualStudio</source>
   <description>SetSite failed for package [Visual Studio Explorers and Designers Package][Object reference not set to an instance of an object.]:{   at Microsoft.VSDesigner.VSDMenus.Initialize(IServiceProvider serviceProvider)
   at Microsoft.VSDesigner.VSDesignerPackage.VSDesignerPackage.Initialize()
   at Microsoft.VisualStudio.Shell.Package.Microsoft.VisualStudio.Shell.Interop.IVsPackage.SetSite(IServiceProvider sp)}</description>
   <guid>{8D8529D3-625D-4496-8354-3DAD630ECC1B}</guid>
   <hr>80004003 - E_POINTER</hr>
   <errorinfo>Object reference not set to an instance of an object.</errorinfo></entry>
I followed suggestions found in a similar question but with no success.
Unfortunately re-installing NuGet via Extensions and Updates doesn't solve the issue.
If @batressc solution doesn't work, you have to delete the .VS folder in the solution folder also.  
So:
C:\Users\<username>\AppData\Local\Microsoft\VisualStudio\14.0\ComponentModelCache
[Solution Folder]\.vs
Delete the file Microsoft.VisualStudio.Default.Cachein the folder C:\Users\<username>\AppData\Local\Microsoft\VisualStudio\14.0\ComponentModelCache
This one helps with VS 2017: https://developercommunity.visualstudio.com/content/problem/160124/failed-to-load-package-monoandroiddesignerpackage.html
1) Start VS
2) File->New->Project->Xamarin app (either iOS or Android)
3) Now click the Toolbox
4) Close VS
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