This follows my post here: OpenCV - Remove "white" artifacts from image and fit a curve
I removed the extraneous white points in the image by looking for points across the diagonal at any given location. My result now looks like this:

Now, I would like to fit a curve to the remaining points in the image. I have been looking through previous posts in OpenCV where some have suggested approxPolyDP. Is there a simpler way of fitting a curve and displaying it in OpenCV? 
The idea here using Hough curves was a little too elaborate for me since my image is essentially binary: http://homepages.inf.ed.ac.uk/rbf/BOOKS/BANDB/LIB/bandb4_3.pdf
The final image is a (0-255) grayscale image of w256 x h1024.
EDIT
I just connected the points in the image using line segments. However, I would like to connect the points by fitting a smooth curve to all of them. I have searched SO for such a method and could not find a way.

I think that catmul-rom spline will be a good choice for your task.
You can find implementation here: http://www.codeproject.com/Articles/30838/Overhauser-Catmull-Rom-Splines-for-Camera-Animatio
Answer for AHF's comment (put it here by Qix advice):
This code sketch allows you to edit spline with mouse it uses the files from this link (attach to your project: overhauser.cpp overhauser.hpp and vec3.hpp):
Left mouse button adds/moves a point, right removes.
The code is not very difficult, so I've made 1-channel modification (for compactness).
I guess you'll catch the idea.

#include <iostream>
#include <vector>
#include <stdio.h>
#include <functional>
#include <algorithm>
#include <numeric>
#include <cstddef>
#include "opencv2/opencv.hpp"
#include <iostream>
#include <fstream>
#include "overhauser.hpp"
using namespace std;
using namespace cv;
Mat result;
Mat Img;
vector<cv::Point2f> pts;
Mat curvesImg;
int selectedPt=-1;
CRSpline* spline = 0;
unsigned char LUT_RED[256];
// a case-insensitive comparison function:
bool mycomp (Point2f p1, Point2f p2)
{
    return p1.x<p2.x;
}
float dist(Point2f p1,Point2f p2)
{
    return sqrt((p1.x-p2.x)*(p1.x-p2.x)+(p1.y-p2.y)*(p1.y-p2.y));
}
int findNEarestPt(Point2f pt, float maxDist)
{
    float minDist=FLT_MAX;
    int ind=-1;
    for(int i=0;i<pts.size();++i)
    {
        float d=dist(pt,pts[i]);
        if(minDist>d)
        {
            ind=i;
            minDist=d;
        }
    }
    if(minDist>maxDist)
    {
        ind=-1;
    }
    return ind;
}
float F(float t,float x)
{
  vec3 rv = spline->GetInterpolatedSplinePoint(t);
  return x-rv.x;
}
float solveForX(float x)
{
    float a=0,b=1.0,c,e=1e-5;
    c=(a+b)/2;
    while( (fabs(b-a)>e) && (F(c,x)!=0) )
    {
        if (F(a,x)*F(c,x)<0)
        {
            b=c;
        }
        else
        {
            a=c;
        }
        c=(a+b)/2;
    }
return c;
}
int ind=-1;
void mouseHandler(int event, int x, int y, int flags, void* param)
{
    Point2f m;
    m.x=x;
    m.y=y;
    curvesImg=Scalar(0,0,0);
    switch (event)
    {
    case cv::EVENT_RBUTTONDOWN:
        ind=findNEarestPt(m,5);
        if (ind==-1)
        {
        }else
        {
            pts.erase(pts.begin()+ind);
            ind=-1;
        }
        break;
    case cv::EVENT_LBUTTONDOWN:
        ind=findNEarestPt(m,5);
        if (ind==-1)
        {
            pts.push_back(m);
            selectedPt=pts.size()-1;
        }else
        {
            selectedPt=ind;
        }
        break;
    case cv::EVENT_MOUSEMOVE:
        if(ind!=-1)
        {
            pts[selectedPt].x=m.x;
            pts[selectedPt].y=m.y;
        }
        break;
    case cv::EVENT_LBUTTONUP:
        ind=-1;
        break;
    }
    std::sort(pts.begin(),pts.end(),mycomp);
    if(pts.size()>0)
    {
        pts[pts.size()-1].x=curvesImg.cols;
        pts[0].x=0;
    }
    for(int i=0;i<pts.size();++i)
    {
        circle(curvesImg,pts[i],5,Scalar(0,255,255),-1,CV_AA);
    }
    if (spline) {delete spline;}
    spline = new CRSpline();
    for (int i=0;i<pts.size();++i)
    {
        vec3 v(pts[i].x,pts[i].y,0);
        spline->AddSplinePoint(v);
    }
    vec3 rv_last(0,0,0);
    if(pts.size()>2)
    {
        for(int i=0;i<256;++i)
        {
            float t=solveForX(i);
            vec3 rv = spline->GetInterpolatedSplinePoint(t);
            unsigned char I=(unsigned char)(rv.y);
            LUT_RED[i]=255-I;
            if(i>1)
            {
                line(curvesImg,Point(rv.x,rv.y),Point(rv_last.x,rv_last.y),Scalar(0,0,255),1);
            }
            rv_last=rv;
        }
    }
    line(curvesImg,Point(0,m.y),Point(curvesImg.cols,m.y),Scalar(0,255,0),1);
    line(curvesImg,Point(m.x,0),Point(m.x,curvesImg.rows),Scalar(0,255,0),1);
    imshow("Result",curvesImg); 
    vector<Mat> ch;
    cv::split(Img,ch);
    LUT(ch[2],Mat(256,1,CV_8UC1,LUT_RED),ch[2]);
    cv::merge(ch,result);
    imshow("Transformed",result);   
}
// ---------------------------------
// 
// ---------------------------------
//==============================================================================
int main( int argc, char** argv )
{
    for (int i=0;i<256;++i)
    {
        LUT_RED[i]=i;
    }
    namedWindow("Image",cv::WINDOW_NORMAL);
    namedWindow("Result");
    namedWindow("Transformed");
    Img=imread("D:\\ImagesForTest\\lena.jpg",1);
    imshow("Image",Img);
    curvesImg=Mat::zeros(256,256,CV_8UC3);
    setMouseCallback("Result", mouseHandler, NULL);
    waitKey(0);
    getchar();
}
If you love us? You can donate to us via Paypal or buy me a coffee so we can maintain and grow! Thank you!
Donate Us With