I'm looking at using CouchDB for one project and the GAE app engine datastore in the other. For relational stuff I tend to use postgres, although I much prefer an ORM.
Anyway, what use cases suit non relational datastores best?
Here is a nice little article (spread over three pages) that covers the use-case for non-relational databases.
http://www.readwriteweb.com/enterprise/2009/02/is-the-relational-database-doomed.php
In a nutshell, when you need massive scalability then you probably need a non-realtional db. Of course, you may well end up writing a lot more code to do what a relational db does for you, but if you really need that scalability, then the relational db option is usually more expensive, and very tricky to architect properly.
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