I am using apache's activemq for queueing. We have started to see the following exception very often when writing things to the queue:
Caused by: org.apache.activemq.transport.InactivityIOException: Cannot send, channel has already failed: 
    at org.apache.activemq.transport.AbstractInactivityMonitor.doOnewaySend(AbstractInactivityMonitor.java:282)
    at org.apache.activemq.transport.AbstractInactivityMonitor.oneway(AbstractInactivityMonitor.java:271)
    at org.apache.activemq.transport.TransportFilter.oneway(TransportFilter.java:85)
    at org.apache.activemq.transport.WireFormatNegotiator.oneway(WireFormatNegotiator.java:104)
    at org.apache.activemq.transport.MutexTransport.oneway(MutexTransport.java:68)
    at org.apache.activemq.transport.ResponseCorrelator.asyncRequest(ResponseCorrelator.java:81)
    at org.apache.activemq.transport.ResponseCorrelator.request(ResponseCorrelator.java:86)
    at org.apache.activemq.ActiveMQConnection.syncSendPacket(ActiveMQConnection.java:1366)
I can't figure out what could be causing this-- or even, frankly, where to start debugging what is causing this.
Here is the queue set up code:
    camelContext = new DefaultCamelContext();
    camelContext.setErrorHandlerBuilder(new LoggingErrorHandlerBuilder());
    camelContext.getShutdownStrategy().setTimeout(SHUTDOWN_TIMEOUT_SECONDS);
    routePolicy = new RoutePolicy();
    routePolicy.setCamelContext(camelContext);
    ActiveMQConnectionFactory connectionFactory = new ActiveMQConnectionFactory();
    connectionFactory.setBrokerURL(queueUri);
    // use a pooled connection factory between the module and the queue
    pooledConnectionFactory = new PooledConnectionFactory(connectionFactory);
    // how many connections should there be in the session pool?
    pooledConnectionFactory.setMaxConnections(this.maxConnections);
    pooledConnectionFactory.setMaximumActiveSessionPerConnection(this.maxActiveSessionPerConnection);
    pooledConnectionFactory.setCreateConnectionOnStartup(true);
    pooledConnectionFactory.setBlockIfSessionPoolIsFull(false);
    JmsConfiguration jmsConfiguration = new JmsConfiguration(pooledConnectionFactory);
    jmsConfiguration.setDeliveryPersistent(false); // do not store a copy of the messages on the queue
    ActiveMQComponent activeMQComponent = ActiveMQComponent.activeMQComponent(queueUri);
    activeMQComponent.setConfiguration(jmsConfiguration);
    camelContext.addComponent("activemq", activeMQComponent);
    Component activemq = camelContext.getComponent("activemq");
    // register endpoints for queues and topics
    Endpoint queueEndpoint = activemq.createEndpoint("activemq:queue:polaris.*");
    Endpoint topicEndpoint = activemq.createEndpoint("activemq:topic:polaris.*");
    producerTemplate = camelContext.createProducerTemplate();
    camelContext.start();
    queueEndpoint.start();
    topicEndpoint.start();
Like I said, the error doesn't suggest any directions for debugging, and it doesn't happen in 100% of cases where I can be sure my configuration is not set up correctly.
Recently I ran into the same problem. I found this https://issues.apache.org/jira/browse/AMQ-6600
Apache ActiveMQ client throws InactivityIOException when one of the jars is missing in classpath. In my case it was hawtbuf-1.11.jar. When I added this jar to classpath it started to work without errors.
Check, if there is a non-Jms client pinging your JMS broker. This may be an external monitoring tool, a load balancing tool such as keepalived, or another one.
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