To remove a plug-in you need to remove the JAR file from the "plugins" directory, located in your Eclipse installation directory. Under Indigo/3.7 the "Help > About Eclipse > Installation Details > Installed Software tab > Uninstall..." option works.
Go to Plugins. Go to Installed Plugins. Click Deactivate for the plugin you want to uninstall (you must deactivate it before you can delete it).
To uninstall you should either go on and remove the org. python. pydev* from eclipse/plugins and eclipse/features or you can go to help > software updates > manage configuration, choose the PyDev plugin and disable it (after that, to completely remove it, you must restart Eclipse and only then select it for uninstall).
Using the menus, open
In the "Installed software" tab click on the software that you wish to uninstall, then click the "Uninstall..." button below.
If you installed the plug-in by dropping into the dropins folder, then just delete it from the dropins folder and restart Eclipse.
See the answer of @Cogentleman for more recent versions of Eclipse.
I would like to propose my solution,that worked for me.
It's reverting Eclipse and its plugins versions, to the version just before the plugin was installed.
Eclipse Photon user here, found it under the toolbar's Windows > Preferences > Install/Update > "Uninstall or update" link > Click stuff and hit the "Uninstall" button.

I'm using Eclipse Kepler release. There is no Installation Details or About Eclipse menu item under help. For me, it was Help | Eclipse Marketplace...
I had to click on the "Installed" tab. The plug-in I wanted to remove was listed there, with an "Uninstall" option.
There are few things to keep in mind:
'Uninstalling' a feature, using the steps above, disable the feature or plug-in.
They are still available on disk, and they can be enabled at any time in the future.
Completely removing a Plugin from the system requires a manual process that should be done when Eclipse is not running.
In order to do this, If you are removing a feature you will have to manually remove the files there associated with the feature from the eclipse/features directory and its plug-ins from the eclipse/plugins directory.
If you are removing a plugin you will have to manually remove the files there associated with the plugin from the eclipse/plugins directory.
From the FAQ of Eclipse:
Be very cautious as to which files you delete, and always have a backup of your Eclipse directory. If you remove the wrong files from these directories, you may have quite some trouble restoring your Eclipse to a stable state. Therefore, unless your hard disk storage capacity is extraordinarily limited, it is recommended that you simply leave the physical files in place.
- Note that when manually removing plugins as described above, it is likely that some metadata will still cached by Eclipse. This can lead to problems later on. Running Eclipse with the -clean option may help with that, as it causes Eclipse to clean the cached metadata. See the Running Eclipse help page for details about this option.
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